INTRODUCTION

DAPAMECH:

This is a series of mechanistic trials that will continue to advance our understanding of the underlying science behind the CV and renal effects of dapagliflozin.

THE DAPAMECH

HF disease-specific biomarkers, symptoms, health status, and QoL in patients with T2D and chronic HF with reduced systolic function

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HF disease-specific biomarkers, symptoms, health status, and QoL in patients with T2D or prediabetes and chronic HF with preserved systolic function

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The natriuretic effect in patients with T2D with preserved or impaired renal function and ND patients with impaired renal function

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Insulin sensitivity in skeletal muscle in patients with T2D taking no diabetes medication or metformin only

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Cardiac substrate uptake, myocardial efficiency and myocardial contractile work in patients with T2D

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The renoprotective effects in nondiabetic patients with proteinuria and on stable dose of ACEi or ARB

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DISCLAIMER

The effects listed above are not included in the indications for dapagliflozin. Please consult your local prescribing information for the approved use of dapagliflozin. 

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